Background: Breast cancer (BC) remains a growing public health challenge globally. It has been the most common form of cancer and the second most common cause of cancer death in women after cancer of the cervix-uteri in sub- Saharan Africa. Women in Nigeria have comparably low incidence rates of breast cancer worldwide. However, the expensive treatment and poor survival rates from this disease results in a disease and mortality burden as high as in high-incidence countries. The African Breast Cancer - Disparities in Outcome (ABC-DO) cohort of African breast cancer patients, showed that breast cancer diagnosis and its deaths have a significant influence and impact not only on the patients, but also understandably on their spouses and children. Such impacts include impact on their health, education, social support, financial, and psychological, emotional, and physical distress. These can usually result in considerable household disruption and are amplified in low- and middle-income countries (LMICs), including Nigeria. Given the family-oriented structure in Nigerian society, Breast cancer can have a devastating effect on the family. 
Aim: The study investigates the impact of mothers’ breast cancer diagnosis, treatment, and survival on their children in Nigeria.
Methods: We conducted semi-quantitative interviews in 300 Nigerian children from three comparison groups: Two groups were recruited from children of mothers that previously participated in the ABC-DO study. Of these 100 children were from mothers that died from breast cancer, and 100 children from breast cancer survivors. A third group consisted of 100 children of disease-free mothers from the general population, matched by residential area, age, and sex, selected using snowball and random sampling. Children were interviewed via a context-adopted version of the Child, Caregiver & Household Well-being Survey Tools for Orphans & Vulnerable Children (OVC).  The recruitment of subjects was between 2024 and August 2025. The collected data using KoboCollect was imported to R for analysis. Logistic regression was used to estimate multivariate odds ratios (ORs) with 95% confidence intervals (CIs). A p-value of less than or equal to 0.05 (p</= 0.05) was considered statistically significant.
Results: First preliminary results suggest significantly poorer health, psychosocial, educational, and economic outcomes among children of breast cancer-affected mothers, particularly those whose mothers are deceased, compared to children of disease-free mothers.
Conclusion: These findings are anticipated to bring to light breast cancer as a family-level public health issue and highlight the need for integrated, child-sensitive cancer care and social protection policies in Nigeria and similar low-resource settings.