Background: The CureAll framework underpins the Global Initiative for Childhood Cancer (GICC), launched in 2018 by WHO with St. Jude Children's Research Hospital and global partners, including IARC, to increase childhood cancer survival to 60% by 2030, while reducing suffering for all. In many settings, critical data gaps persist.  A cornerstone of the CureAll framework is the E pillar, focused on Evaluation and monitoring, with quality assurance and information systems.
 
Objectives: With the completion of the first phase of GICC (2018-2025), it is critical to examine countries’ reported efforts in the E pillar.  
 
Methods: As the WHO Collaborating Centre for Childhood Cancer, St. Jude Global has worked with WHO Headquarters and Regional Offices from GICC’s inception to invite engaged countries to submit updates across the CureAll pillars via Ministry/WHO Country Office focal points via structured templates. Submissions reviewed by three or more analysts and iteratively updated in the CureAll Progress dashboard maintained by St. Jude Global. To examine E pillar efforts, dashboard data was analyzed to capture relevant implementation activities, projects and deliverables. 
 
Results: To date, 87 countries across six WHO regions and all World Bank economies are engaged in GICC, including 53 Focus Countries (with formalized Ministry engagements),12 Countries with Activities, and 22 Countries in Dialogue.  As of December 2025, 48 GICC countries reported implementation activities linked to the E Pillar, resulting in 75 projects and 68 deliverables. More than half of these projects (39; 52%) related to CureAll Core Project 8, with 23 (54%) countries across all regions reporting on efforts establishing, strengthening or linking population-based and hospital-based cancer registries (PBCRs and HBCRs).  Focus of projects ranged from situational analyses and standard operating procedures/workflows for childhood cancer registration, to workforce capacity building and HBCR networks, to investing in knowledge generation and innovation, including outcome analyses, data centers/units for childhood cancer research and clinical trials, and registry-linked biobanking.  Deliverables reported included PBCR/HBCR training manuals/packages, epidemiological and registry reports, data quality assessments, regional indicators and country dashboards for monitoring, and legal frameworks for national childhood cancer registration.  Featured resources included SJCARES Registry, and ChildGICR, an IARC/St. Jude Global collaboration to strengthen childhood cancer registration.  Countries noted the importance of considering stakeholders, logistics and distinct needs across sites, and aligning towards common goals of data use, including establishing national estimates of survival and economic outcomes with sustained government support.  Globally, more than 400 CureAll projects across pillars have been reported, engaging more than 3,000 pediatric hematologists/oncologists across more than 650 hospitals, with estimated impact altogether reaching over 500,000 children and adolescents with cancer worldwide. 
 
Conclusions/Implications: The CureAll framework has provided a mechanism for countries to mobilize collaborative progress in childhood cancer control, and to share featured projects and deliverables.
Diverse E Pillar initiatives across GICC countries highlight the prioritization of data for country insights, and the urgency for ongoing monitoring and evaluation efforts, integrated and prioritized in national systems, to inform national policy and programmes to drive progress towards the global 2030 targets to save one million more children and adolescents.